Determination of Quetiapine in Pharmaceutical Dosage Form

The advantages of the therapeutic profile of quetiapine have led to increasing use in the clinical practice, which encourages the development of new analytical method to provide driving force in today’s pharmaceutical industry. Higher sample throughput with more information per sample may decrease the time to market, an important driving force in today’s pharmaceutical industry [1-3]. UPLC is a new category of separation technique based upon well-established principles of liquid chromatography, which utilizes sub-2 μm particles for stationary phase. These particles operate at elevated mobile phase linear velocities to affect dramatic increase in resolution, sensitivity and speed of analysis. Owing to its speed and sensitivity, this technique is gaining considerable attention in recent years for pharmaceuticals and biomedical analysis.